منابع مشابه
Stability puzzles in phage lambda.
In the absence of RecA-mediated cleavage of the repressor, the lambda prophage is exceptionally stable. We develop a stochastic model that predicts the stability of such epigenetic states from affinities of the molecular components. We find that the stability, in particular, depends on the maximum possible cI protein production, and on the number of translated cro proteins per transcribed mRNA....
متن کاملTowards the Understanding of Stability Puzzles in Phage lambda
In their elegant work 1 Aurell and Sneppen developed a framework to quantify the robustness of a biological state. They have successfully applied their formulation to the robustness of the epigenetic state of the wild type phage λ, but concluded, and supported by their further numerical study 2 , that their model is not robust against various mutations in the gene regulatory network of phage λ....
متن کاملRecombinant λ-phage nanobioparticles for tumor therapy in mice models
Lambda phages have considerable potential as gene delivery vehicles due to their genetic tractability, low cost, safety and physical characteristics in comparison to other nanocarriers and gene porters. Little is known concerning lambda phage-mediated gene transfer and expression in mammalian hosts. We therefore performed experiments to evaluate lambda-ZAP bacteriophage-mediated gene transfer a...
متن کاملIonic switch controls the DNA state in phage λ
We have recently found that DNA packaged in phage λ undergoes a disordering transition triggered by temperature, which results in increased genome mobility. This solid-to-fluid like DNA transition markedly increases the number of infectious λ particles facilitating infection. However, the structural transition strongly depends on temperature and ionic conditions in the surrounding medium. Using...
متن کاملPopulation Dynamics of Phage and Bacteria in Spatially Structured Habitats Using Phage λ and Escherichia coli.
UNLABELLED Bacteria living in physically structured habitats are exposed heterogeneously to both resources and different types of phages. While there have been numerous experimental approaches to examine spatially distributed bacteria exposed to phages, there is little theory to guide the design of these experiments, interpret their results, or expand the inferences drawn to a broader ecologica...
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ژورنال
عنوان ژورنال: Physical Review E
سال: 2002
ISSN: 1063-651X,1095-3787
DOI: 10.1103/physreve.65.051914